Gene dosage effect of pfkfb3
WebDec 29, 2024 · Some cells become diseased because certain genes work incorrectly or no longer work at all. Replacing the defective genes may help treat certain diseases. For instance, a gene called p53 normally prevents tumor growth. Several types of cancer have been linked to problems with the p53 gene. Webtitle = "Gene-dosage effect of Pfkfb3 on monocyte/macrophage biology in atherosclerosis", abstract = "BACKGROUND AND PURPOSE: Macrophage-rich atherosclerotic arteries are highly active in glycolysis. PFKFB3, a key glycolytic enzyme, has emerged as a potential therapeutic target in atherosclerosis.
Gene dosage effect of pfkfb3
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WebSince PFKFB3, unlike PFKFB4, has been established to function as a kinase in transformed cells, we next examined the effect of PFKFB3 siRNA transfection on three transformed cell lines and... WebAug 3, 2024 · PFKFB3, a key glycolytic enzyme, has emerged as a potential therapeutic target in atherosclerosis. Small-molecule inhibitors of PFKFB3, such as 3PO and …
WebAbout the Study. Atherosclerotic plaque formation and progression are a result of a chronic non-resolving inflammatory response involving a constant expansion and infiltration of monocytes and impaired clearance of dying macrophages within the plaque [].Therefore, the mechanisms regulating the expansion and recruitment of monocytes as well as the death … WebJul 8, 2024 · g Genetic knockdown of PFKFB3 inhibits glucose uptake in spheroids of H1048 and H1882 (Scale bar, 100 μm) and (h) Bar graph shows percentage of glucose …
WebAug 3, 2024 · Introduction. The liver is not only the most important organ for metabolism and detoxification but also the main site of many biological processes (1-4).Indeed, the liver plays a very important role in metabolism (), bile production (), detoxification (), blood coagulation (), immunity (), and heat generation as well as the regulation of water and … WebHigh-throughput genomic analyses have shown that many mutations, including loss-of-function (LOF) mutations, are present in diseased as well as in healthy individuals. Gene dosage effects due to deletions, duplications, and LOF mutations provide avenues to explore oligo- and multigenic inheritance.
WebRNA sequencing showed that shear stress reduced the expression of key glycolytic enzymes, such as 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-3 (PFKFB3), phosphofructokinase-1, and hexokinase 2 in a KLF2-dependent manner. Moreover, KLF2 represses PFKFB3 promoter activity.
WebMar 11, 2024 · Phosphofructokinase-2/fructose-2,6-bisphosphotase (PFKFB) is a bifunctional enzyme that catalyzes the synthesis and hydrolysis of F-2,6-BP. F-1.6-BP … drawers for craft suppliesWebMoreover, these increases in PFKFB3 mRNA and protein expression and Fru-2,6-P 2 concentration were reduced when the Smad3, p38 mitogen-activated protein kinase (MAPK), and phosphoinositide 3-kinase (PI3K)/Akt signaling pathways were inhibited. drawers for flight casesWebAug 12, 2024 · Systemic, partial PFKFB3 inhibition previously decreased total plaque burden and increased plaque stability. However, it is unclear which cell type conferred these positive effects. Myeloid cells play an important role in atherogenesis, and mainly rely on glycolysis for energy supply. drawers for corner kitchen cabinetsdrawers for folding tablesWebGenetic studies elucidating the role of Pfkfb3 in atherogenesis need to be conducted to validate pharmacological findings and to unveil potential pharmacological side … employee services agency santa claraWebApr 12, 2024 · Nanocarriers passively accumulate in solid tumors through irregular wide fenestrations in neovasculature and increased retention due to poor lymphatic drainage, a phenomenon termed the enhanced permeation and retention (EPR) effect. Although several preclinical reports have described the role of EPR in nanomedicine, its role in human … employee service rewardsWebThe "gene dosage effect" hypothesis states that the phenotype is a direct result of the cumulative effect of the imbalance of the individual genes located on the triplicated chromosome or chromosome region. In a nut shell, the phenotype results directly from the overexpression of specific chromosome 21 genes. drawers for desk with no drawers